Synthesis of Novel 2-diethylamino-4H-7-(Het) aryl pyrido[1,2-a][1,3,5]triazin-4-ones via a Suzuki Cross-Coupling Reaction of 2-Diethylamino-4H-7-iodopyrido[1,2a][1,3,5]triazin-4-one with (Het) arylboronic Acids in Water

Suzuki cross coupling reaction is one of the most famous organic reactions 20th century’s chemistry. It deemed as in field a very effective method for making carbon–carbon bonds. has been extensively utilized synthesis many carbon molecules including complex ones.Syntheses 2-diethylamino-4H-7-(Het) aryl pyrido [1,2-a] [1,3,5] triazin-4-ones are currently under investigation order to obtain great potentialities medicinal chemistry compounds class. The methodology we propose herein able produce numerous 2-diethylamino-4H-7-(Het)arylpyrido[1,2-a][1,3,5]triazin-4-one and derivatives that were synthesized, purified characterized by 1HNMR, 13CNMR, MS techniques. Furthermore, it allows sequential introduction various substituents into 2-alkylylamino-4H-7-(Het)arylpyrido[1,2-a][1,3,5]triazin-4-ones ring using one-pot procedure. biological evaluation well physico-chemical characterisation products way will be described elsewhere.